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Pro-Test: Five Year Anniversary – Friday 25^th February 2011

Five years ago, in a climate of fear and harassment from animal rights extremists, 1,000 students, staff and members of the public marched through the centre of Oxford to defend life-saving medical research.

Led by a 16-year-old student, Laurie Pycroft, the Pro-Test rally helped change the attitudes of public, politicians and media towards animal research in the UK.

On Friday February 25^th 2011 Pro-Test are holding a series of events to celebrate the progress Pro-Test has made over the last five years.

From 12 – 2pm Pro-Test will be manning a series of stalls on Cornmarket in order to show its continued efforts to educate the public about the crucial role of animals in medical research. Come along and support the cause!

At 4pm Pro-Test members will head online to Nature’s live Q&A on the animal research issue (link). Pro-Test members have already provided background articles for Nature to support this event.

At 7.15pm (Lecture Theatre 23, Balliol College) Pro-Test will hold a discussion in conjunction with the Philosophy, Politics and Economics Society (PPE Soc) to talk about how Pro-Test’s efforts have helped to shift the public attitude on animal research. Speakers will be:

• Laurie Pycroft – Founder of Pro-Test and currently an undergraduate at Oxford University – Pycroft will talk about the birth and growth of the Pro-Test movement in the UK
• Prof. Tipu Aziz – Consultant Neurosurgeon at Oxford University – Prof. Aziz will give his views on the changing climate of research at Oxford University and beyond
• Tom Holder – Founder of Speaking of Research, Pro-Test’s US sister-organisation formed in 2008. Holder will discuss successful campaigning methods, and the lessons learned from the UK and US pro-research movements.

University members will be required to bring their university card. Non-university members should email tom[at]pro-test.org.uk to book tickets.

We look forward to seeing you there.

Pro-Test

If you have watched TV in the past week or two, you may have seen the excellent ads produced by the British Heart Foundation (BHF) as part of a major fundraising drive to support their new Mending Broken Hearts campaign.

The Mending Broken Hearts campaign is a major new multidisciplinary initiative which seeks to harness the power of regenerative medicine to better treat, and one day cure, heart failure. If you want to learn more about this work, the BHF website has information on the science behind the initiative, and why their scientists are studying zebrafish.

It is an ambitious and fascinating project, and an excellent example of how the differences between species can be as valuable to medical advancement as the similarities.

But that’s not all that is striking about this campaign.

This is a fundraising campaign by a major medical research charity that not only acknowledges the importance of animal research, but places it centre stage. Little more than a decade ago that would have been unthinkable.

When I first started my career in science in the late 1990’s public support for animal research in the UK was considerably lower than it is now, and few scientists willing to discuss their work in public or counter the misleading propaganda of animal rights activists. Animal rights extremists appeared to be able to harass, intimidate and coerce at will, using tactics such as hate mail, vandalism, arson, grave robbing and violence to force several animal breeders to close, and even contributing to a decision by Cambridge University to abandon plans to construct a new primate laboratory in 2004. As the 21^st century dawned the future of biomedical research in the UK looked very bleak.

But behind the scenes things were changing. The tireless efforts of research advocacy groups including RDS and the Coalition for Medical Progress (now merged to form Understanding Animal Research ), Sense about Science, and Seriously Ill for Medical Research, who spoke up for animal research and countered the distortions spread by animal research, and the bravery of individuals including the Oxford neuroscientist Professor Colin Blakemore and patient activist Andrew Blake, who continued to speak out in support of animal research despite threats against themselves and their families, began to yield dividends. As time went on more and more scientists were persuaded to discuss the role of animal research in their work in more detail when talking to journalists, rather than referring obliquely to “laboratory studies”, and by the middle of the decade opinion polls indicated that public support for the use of animals in medical research had increased dramatically. Politicians also began to wake up to the threat posed to science in the UK by animal rights extremism, and the danger that other unrepresentative minorities might adopt the tactics of animal rights extremists to foist their views on the rest of society: Something had to be done. A series of laws were passed to prevent intimidation and harassment being used as campaign tools, while for the first time sufficient resources were made available to police units to counter domestic extremism.

The tide finally turned in the spring of 2006 when hundreds of citizens, scientists, students in Oxford joined together under the banner of Pro-Test to march in support the construction of a new animal research laboratory. Responding to threats by animal rights extremists, and inspired by the example set by Laurie Pycroft, the marchers showed that they would not be silenced and would not be intimidated. That rally, and the widespread coverage it received in national and international news media, released a pent-up wave of support from animal research that almost instantly changed the tenor of the debate on animal research in the UK. The new Oxford laboratory was completed in 2008.

Now five years later many of the animal rights extremists whose terror campaigns made the lives of so many people a misery are behind bars, and scientists are more willing than ever before to talk about the contribution of animal research to medical progress.

So the zebrafish are not just an example of the promise of 21^st century medicine, but show us that if scientists and supporters of science stand together we can defeat extremism, we can counter the lies and distortions spread by animal rights campaigns, and we can secure the future of scientific medicine. That's a lot of hope for such a small fish.

Paul Browne

Albert Sabin has been called “the doctor who gave summer back to the children.”*

Because of his decades of research to develop the oral polio vaccine, children today know nothing of the fear that polio brought to the United States every summer well into the 20th century. Swimming pools and movie theaters were closed and children were kept inside their homes by frightened parents. Worldwide, the disease killed millions of people and left legions of others permanently disabled.

We’ve just celebrated the 50th anniversary of the introduction of Dr. Sabin’s vaccine. Estimates suggest that in just its first two years of worldwide use, the vaccine prevented nearly 500,000 deaths and five million cases of polio. Today, the world is on the brink of realizing Dr. Sabin’s lifetime dream: the eradication of polio from the planet.

The development of the oral polio vaccine required years of extensive research with rabbits, monkeys and rodents.

Animal rights activists long ago seized on a single phrase by Dr. Albert Sabin, and have been using it ever since to try to support their outrageous claim that the developer of the oral polio vaccine(OPV) opposed the use of animals in research.

That phrase, “The work on prevention (of polio) was long delayed by an erroneous conception of the nature of the human disease based on misleading experimental models of disease in monkeys” spoken by Dr. Sabin during a congressional hearing in 1984, has been used in animal rights publications and comments for over two decades.

Dr. Sabin, a member of the Board of Directors of the pro-research Americans for Medical Progress until his death in 1993, spent years working to correct the record. Here is a letter he wrote to the editor of the Winston Salem Journal, published in 1992.

Winston-Salem Journal

March 20, 1992

The Correct Conclusion

In a recent letter to the Journal (“Misrepresenting Research,” Feb. 20), Dr. Stephen R. Kaufman, the chairman of the Medical Research Modernization Committee, correctly quoted my 1984 testimony before Congress but he drew wrong conclusions from it. Dr. Kaufman was also wrong when the said “the polio vaccine was based on a tissue culture preparation … not animal experimentation.”

On the contrary, my own experience of more than 60 years in biomedical research amply demonstrated that without the use of animals and of human beings, it would have been impossible to acquire the important knowledge needed to prevent much suffering and premature death not only among humans but also among animals.

In my 1956 paper in the Journal of the American Medical Association (Vol. 162, p. 1589), I stated that during the preceding four years “approximately 9,000 monkeys, 150 chimpanzees and 133 human volunteers were used thus far in studies of various characteristics of different poliovirus strains.” These studies were necessary to solve many problems before an oral polio-virus vaccine could become a reality.

Albert B. Sabin, M.D.

Washington”."

It is true that in the early years of polio research some lines of inquiry eventually proved unsuccessful. An overreliance on a strain of the virus known as the MV strain that had become adapted to survive only in nervous tissue, and the fact that the Rhesus macaque, while a good model for many aspects of polio, cannot be infected through ingestion via the mouth, led to the incorrect assumption that polio could only infect nerve cells (despite evidence to the contrary from both clinical studies and laboratory studies with other polio strains and monkey species). These mistakes were unfortunate, though understandable given the fact that virology as a science was in its infancy.

However, these failed attempts do not cancel out the fact that animal research, and research using monkeys in particular, was absolutely crucial to the development of vaccines for polio. Without it the polio vaccine would certainly not have been developed by the end of the 1950’s, and we might even still be waiting for it.

These vital contributions made by animal research to the development of polio vaccines were not limited to the work of Albert Sabin, and include:

(i) The discovery by Karl Landsteiner and Erwin Popper in 1908 that polio was caused by a virus, a discovery made by inoculating macaque monkeys with an extract of nervous tissue from polio victims that was shown to be free of other infectious agents.

(ii) The subsequent discovery by Simon Flexner that blood serum from infected macaque monkeys could protect against polio infection.

(iii) The discovery by Carl Kling and colleagues in 1911, following an earlier discovery that polio virus could be isolated from the lymph nodes of the small intestine of monkeys, that polio virus was present in the throat and intestinal tissues of people who dies from polio. Soon afterwards they isolated virus from the intestines of patients suffering from acute polio, and importantly from family members who did not display the symptoms of polio, establishing that healthy carriers played an important role in spreading the disease. In these studies the presence of polio was demonstrated by injecting filtered fluid from the patients into monkeys, the only method then available to confirm the presence of polio (Introduction to Epidemiology, fifth edition, by Ray M, Merill, Jones and Bartlett Learning).

(iv) The discovery in the early 1930’s by the Australian scientists Macfarlane Burnet and Jean Macnamara that antibodies against one strain of polio did not always protect macaque monkeys against infection with another strain.

(v) The discovery by John Enders, Thomas Weller and Frederick Robbins that the polio virus could be grown in a number of tissue types, not just nerve tissue as previously assumed, a discovery that required the use of mice and monkeys to prove that the cultured virus was indeed polio and still capable of causing paralysis.

(vi) The determination in 1949 by David Bodian and colleagues at Johns Hopkins University that there were three major families of polio virus, referred to as types 1, 2, and 3, and that a separate vaccine would be necessary for each to give broad protection against polio.

(vii) The confirmation by David Bodian and colleagues in the late 1940’s and early 1950’s that the polio virus entered the body through the mouth, and then needed to pass into the blood stream before it could infect nervous tissue, and that if you could block the infection in the blood you could prevent the virus from entering nerve tissue and causing paralysis. The work of Enders and Bodian paved the way for the development of vaccines by Salk and Sabin.

(viii) The evaluation by Jonas Salk and his colleagues at the University of Pittsburgh of vaccine candidates produced by inactivating the virus with formalin under a range of conditions, until a vaccine was identified that was effective and safe enough for human trials.

(ix) The evaluation by Albert Sabin of hundreds of polio virus strains in hundreds of monkeys and scores of chimps before identifying attenuated strains that were capable of efficiently entering the body through the digestive system and provoking an adequate immune response to protect against the different pathogenic strains of polio while not causing the disease themselves.

It is hardly surprising that those close to Albert Sabin are disgusted with the way in which his views are misrepresented by animal rights activists. Writing for the Wall Street Journal two years after his death Albert Sabin’s widow, Heloisa Sabin, discussed the value of animals to his research.

ANIMAL RESEARCH SAVES HUMAN LIVES

The Wall Street Journal, October 18, 1995

by Heloisa Sabin

Mrs. Sabin is honorary director of Americans for Medical Progress.

That scene in "Forrest Gump," in which young Forrest runs from his schoolmate tormentors so fast that his leg braces fly apart and his strong legs carry him to safety may be the only image of the polio epidemic of the 1950s etched in the minds of those too young to remember the actual devastation the disease caused. Hollywood created a scene of triumph far removed from the reality of the disease.

Some who have benefited directly from polio research, including the work of my late husband, Albert Sabin, think winning the real war against polio was just as simple. They have embraced a movement that denounces the very process that enables them to look forward to continued good health and promising futures. This "animal rights" ideology -- espoused by groups such as People for the Ethical Treatment of Animals, the Humane Society of the U.S. and the Fund for Animals -- rejects the use of laboratory animals in medical research and denies the role such research played in the victory over polio.

The leaders of this movement seem to have forgotten that year after year in the early '50s, the very words "infantile paralysis" and "poliomyelitis" struck great fear among young parents that the disease would snatch their children as they slept. Each summer public beaches, playgrounds and movie theaters were places to be avoided. Polio epidemics condemned millions of children and young adults to lives in which debilitated lungs could no longer breathe on their own and young limbs were left forever wilted and frail. The disease drafted tiny armies of children on crutches and in wheelchairs who were unable to walk, run or jump. In the U.S., polio struck down nearly 58,000 children in 1952 alone.

Unlike the braces on Forrest Gump's legs, real ones would be replaced only as the children's misshapened legs grew. Other children and young adults were entombed in iron lungs. The only view of the world these patients had was through mirrors over their heads. These, however, are no longer part of our collective cultural memory.

Albert was on the front line of polio research. In 1961, thirty years after he began studying polio, his oral vaccine was introduced in the U.S. and distributed widely. In the nearly 40 years since, polio has been eradicated in the Western hemisphere, the World Health Organization reports, adding that with a full-scale effort, polio could be eliminated from the rest of the world by the year 2000.

Without animal research, polio would still be claiming thousands of lives each year. "There could have been no oral polio vaccine without the use of innumerable animals, a very large number of animals," Albert told a reporter shortly before his death in 1993. Animals are still needed to test every new batch of vaccine that is produced for today's children.

Animal activists claim that vaccines really didn't end the epidemics -- that, with improvements in social hygiene, polio was dying out anyway, before the vaccines were developed. This is untrue. In fact, advanced sanitation was responsible in part for the dramatic rise in the number of paralytic polio cases in the '50s. Improvements in sanitation practices reduced the rate of infection, so that the average age of those infected by the polio virus went up. Older children and young adults were more likely than infants to develop paralysis from their exposure to the polio virus.

Every child who has tasted the sweet sugar cube or received the drops containing the Sabin Vaccine over the past four decades knows polio only as a word, or an obscure reference in a popular film. Thank heavens it's not part of their reality.

These polio-free generations have grown up to be doctors, teachers, business leaders, government officials, and parents. They have their own concerns and struggles. Cancer, heart disease, strokes and AIDS are far more lethal realities to them now than polio. Yet, those who support an "animal rights" agenda that would cripple research and halt medical science in its tracks are slamming the door on the possibilities of new treatments and cures.

My husband was a kind man, but he was impatient with those who refused to acknowledge reality or to seek reasoned answers to the questions of life.

The pioneers of polio research included not only the scientists but also the laboratory animals that played a critical role in bringing about the end of polio and a host of other diseases for which we now have vaccines and cures. Animals will continue to be as vital as the scientists who study them in the battle to eliminate pain, suffering and disease from our lives.

That is the reality of medical progress.”

Animal rights activists are free to express their opposition to the use of animals in research, but they cannot do so by blatantly robbing society of scientific achievements. This one fact is clear -- if our critics had their way, today millions of children would be dead or disabled from polio and other infectious diseases.

* Of course Jonas Salk is equally, if not even more, deserving of this accolade.